BDBM50161957 4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-amide::CHEMBL180022::HKI-272::N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide::N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide::NERATINIB::US10822334, Compound Neratinib::US11896597, Compound Neratinib::US20230382923, Compound Neratinib

SMILES: CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C

InChI Key: InChIKey=JWNPDZNEKVCWMY-UHFFFAOYSA-N

Data: 54 IC50  447 Kd  7 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 523 hits for monomerid = 50161957   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor [1-773,'NPH',774-1210] (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13.2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Epidermal growth factor receptor [1-769,'ASV',770-1210] (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Epidermal growth factor receptor [T790M,L858R] (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255] (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Ferrochelatase, mitochondrial [R115L] (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.96	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.73	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13.2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13.2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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ATP-binding cassette sub-family C member 3 (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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ATP-binding cassette sub-family C member 2 (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Bile salt export pump (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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ATP-binding cassette sub-family C member 4 (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	59	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	92	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-G-associated kinase (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<14	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.01E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.0200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.0200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	92	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	59	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	5	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.580	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Receptor tyrosine-protein kinase erbB-2 [V777L] (Homo sapiens (Human))	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.390	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	92	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	59	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-4 (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Serine/threonine-protein kinase Nek2 (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	274	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Protein delta homolog 1 (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 4 (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 3 (Human)	BDBM50161957 (CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair