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BDBM50162978 4-(Benzothiazol-6-ylamino)-6-(benzyl-ethyl-amino)-[1,3,5]triazin-2-ol::CHEMBL176078

SMILES: CCN(Cc1ccccc1)c1nc(Nc2ccc3ncsc3c2)[nH]c(=O)n1

InChI Key: InChIKey=CUTRRQNUXLUQCJ-UHFFFAOYSA-N

Data: 9 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50162978   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Insulin receptor


(Homo sapiens (Human))
BDBM50162978
PNG
(4-(Benzothiazol-6-ylamino)-6-(benzyl-ethyl-amino)-...)
Show SMILES CCN(Cc1ccccc1)c1nc(Nc2ccc3ncsc3c2)[nH]c(=O)n1
Show InChI InChI=1S/C19H18N6OS/c1-2-25(11-13-6-4-3-5-7-13)18-22-17(23-19(26)24-18)21-14-8-9-15-16(10-14)27-12-20-15/h3-10,12H,2,11H2,1H3,(H2,21,22,23,24,26)
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Article
PubMed
n/an/a 4.00E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Inhibition of beta IRK tyrosine kinase


J Med Chem 48: 1717-20 (2005)


Article DOI: 10.1021/jm049372z
BindingDB Entry DOI: 10.7270/Q2GM86TF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50162978
PNG
(4-(Benzothiazol-6-ylamino)-6-(benzyl-ethyl-amino)-...)
Show SMILES CCN(Cc1ccccc1)c1nc(Nc2ccc3ncsc3c2)[nH]c(=O)n1
Show InChI InChI=1S/C19H18N6OS/c1-2-25(11-13-6-4-3-5-7-13)18-22-17(23-19(26)24-18)21-14-8-9-15-16(10-14)27-12-20-15/h3-10,12H,2,11H2,1H3,(H2,21,22,23,24,26)
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n/an/a 600n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Inhibition of KDR-induced MAP kinase autophosphorylation assay in HUVEC cells


J Med Chem 48: 1717-20 (2005)


Article DOI: 10.1021/jm049372z
BindingDB Entry DOI: 10.7270/Q2GM86TF
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM50162978
PNG
(4-(Benzothiazol-6-ylamino)-6-(benzyl-ethyl-amino)-...)
Show SMILES CCN(Cc1ccccc1)c1nc(Nc2ccc3ncsc3c2)[nH]c(=O)n1
Show InChI InChI=1S/C19H18N6OS/c1-2-25(11-13-6-4-3-5-7-13)18-22-17(23-19(26)24-18)21-14-8-9-15-16(10-14)27-12-20-15/h3-10,12H,2,11H2,1H3,(H2,21,22,23,24,26)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Inhibition of PDGF-R2 tyrosine kinase


J Med Chem 48: 1717-20 (2005)


Article DOI: 10.1021/jm049372z
BindingDB Entry DOI: 10.7270/Q2GM86TF
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM50162978
PNG
(4-(Benzothiazol-6-ylamino)-6-(benzyl-ethyl-amino)-...)
Show SMILES CCN(Cc1ccccc1)c1nc(Nc2ccc3ncsc3c2)[nH]c(=O)n1
Show InChI InChI=1S/C19H18N6OS/c1-2-25(11-13-6-4-3-5-7-13)18-22-17(23-19(26)24-18)21-14-8-9-15-16(10-14)27-12-20-15/h3-10,12H,2,11H2,1H3,(H2,21,22,23,24,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Inhibition of human Insulin receptor expressed in CHO cells


J Med Chem 48: 1717-20 (2005)


Article DOI: 10.1021/jm049372z
BindingDB Entry DOI: 10.7270/Q2GM86TF
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Mus musculus)
BDBM50162978
PNG
(4-(Benzothiazol-6-ylamino)-6-(benzyl-ethyl-amino)-...)
Show SMILES CCN(Cc1ccccc1)c1nc(Nc2ccc3ncsc3c2)[nH]c(=O)n1
Show InChI InChI=1S/C19H18N6OS/c1-2-25(11-13-6-4-3-5-7-13)18-22-17(23-19(26)24-18)21-14-8-9-15-16(10-14)27-12-20-15/h3-10,12H,2,11H2,1H3,(H2,21,22,23,24,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Inhibition of mouse Fibroblast growth factor receptor 1 expressed in NIH 3T3 fibroblasts


J Med Chem 48: 1717-20 (2005)


Article DOI: 10.1021/jm049372z
BindingDB Entry DOI: 10.7270/Q2GM86TF
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50162978
PNG
(4-(Benzothiazol-6-ylamino)-6-(benzyl-ethyl-amino)-...)
Show SMILES CCN(Cc1ccccc1)c1nc(Nc2ccc3ncsc3c2)[nH]c(=O)n1
Show InChI InChI=1S/C19H18N6OS/c1-2-25(11-13-6-4-3-5-7-13)18-22-17(23-19(26)24-18)21-14-8-9-15-16(10-14)27-12-20-15/h3-10,12H,2,11H2,1H3,(H2,21,22,23,24,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Inhibition of human epidermal growth factor receptor


J Med Chem 48: 1717-20 (2005)


Article DOI: 10.1021/jm049372z
BindingDB Entry DOI: 10.7270/Q2GM86TF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50162978
PNG
(4-(Benzothiazol-6-ylamino)-6-(benzyl-ethyl-amino)-...)
Show SMILES CCN(Cc1ccccc1)c1nc(Nc2ccc3ncsc3c2)[nH]c(=O)n1
Show InChI InChI=1S/C19H18N6OS/c1-2-25(11-13-6-4-3-5-7-13)18-22-17(23-19(26)24-18)21-14-8-9-15-16(10-14)27-12-20-15/h3-10,12H,2,11H2,1H3,(H2,21,22,23,24,26)
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n/an/a 49n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
In vitro inhibition of Vascular endothelial growth factor receptor 2 at 10 uM ATP


J Med Chem 48: 1717-20 (2005)


Article DOI: 10.1021/jm049372z
BindingDB Entry DOI: 10.7270/Q2GM86TF
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM50162978
PNG
(4-(Benzothiazol-6-ylamino)-6-(benzyl-ethyl-amino)-...)
Show SMILES CCN(Cc1ccccc1)c1nc(Nc2ccc3ncsc3c2)[nH]c(=O)n1
Show InChI InChI=1S/C19H18N6OS/c1-2-25(11-13-6-4-3-5-7-13)18-22-17(23-19(26)24-18)21-14-8-9-15-16(10-14)27-12-20-15/h3-10,12H,2,11H2,1H3,(H2,21,22,23,24,26)
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n/an/a 400n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Inhibition of tyrosine protein kinase receptor TIE-2


J Med Chem 48: 1717-20 (2005)


Article DOI: 10.1021/jm049372z
BindingDB Entry DOI: 10.7270/Q2GM86TF
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50162978
PNG
(4-(Benzothiazol-6-ylamino)-6-(benzyl-ethyl-amino)-...)
Show SMILES CCN(Cc1ccccc1)c1nc(Nc2ccc3ncsc3c2)[nH]c(=O)n1
Show InChI InChI=1S/C19H18N6OS/c1-2-25(11-13-6-4-3-5-7-13)18-22-17(23-19(26)24-18)21-14-8-9-15-16(10-14)27-12-20-15/h3-10,12H,2,11H2,1H3,(H2,21,22,23,24,26)
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PubMed
n/an/a 4.30E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Inhibition of c-fms tyrosine kinase


J Med Chem 48: 1717-20 (2005)


Article DOI: 10.1021/jm049372z
BindingDB Entry DOI: 10.7270/Q2GM86TF
More data for this
Ligand-Target Pair