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BDBM50164121 2-{4-[6-(2,6-Dichloro-phenyl)-8-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino]-phenyl}-acetamide::CHEMBL178758

SMILES: Cn1c2nc(Nc3ccc(CC(N)=O)cc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O

InChI Key: InChIKey=URFCMVULTIAJNO-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50164121   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase WEE1


(Homo sapiens (Human))
BDBM50164121
PNG
(2-{4-[6-(2,6-Dichloro-phenyl)-8-methyl-7-oxo-7,8-d...)
Show SMILES Cn1c2nc(Nc3ccc(CC(N)=O)cc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C22H17Cl2N5O2/c1-29-20-13(10-15(21(29)31)19-16(23)3-2-4-17(19)24)11-26-22(28-20)27-14-7-5-12(6-8-14)9-18(25)30/h2-8,10-11H,9H2,1H3,(H2,25,30)(H,26,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 120n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of checkpoint kinase Wee1


Bioorg Med Chem Lett 15: 1931-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.01.079
BindingDB Entry DOI: 10.7270/Q280524M
More data for this
Ligand-Target Pair