BDBM50165276 8-(2-Chloro-5-methoxy-phenylsulfanyl)-9-pent-4-ynyl-9H-purin-6-ylamine::CHEMBL192062

SMILES COc1ccc(Cl)c(Sc2nc3c(N)ncnc3n2CCCC#C)c1

InChI Key InChIKey=ZODASEFDXYBTCV-UHFFFAOYSA-N

Data  1 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50165276   

TargetHeat shock protein HSP 90-alpha(Mus musculus)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50165276(8-(2-Chloro-5-methoxy-phenylsulfanyl)-9-pent-4-yny...)
Affinity DataEC50:  200nMAssay Description:Displacement of 5 nM GM-BODIPY from mouse heat shock protein HSP90-alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50165276(8-(2-Chloro-5-methoxy-phenylsulfanyl)-9-pent-4-yny...)
Affinity DataEC50:  9.60E+3nMAssay Description:Effective concentration of compound against heat shock protein HSP90 determined in normal lung cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50165276(8-(2-Chloro-5-methoxy-phenylsulfanyl)-9-pent-4-yny...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of Hsp90 protein as degradation of HER2 kinase in SKBr3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50165276(8-(2-Chloro-5-methoxy-phenylsulfanyl)-9-pent-4-yny...)
Affinity DataEC50:  1.89E+4nMAssay Description:Effective concentration of compound against heat shock protein HSP90 determined in normal heart cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50165276(8-(2-Chloro-5-methoxy-phenylsulfanyl)-9-pent-4-yny...)
Affinity DataEC50:  4.49E+4nMAssay Description:Effective concentration of compound against heat shock protein HSP90 determined in normal brain cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed