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BDBM50165772 (R)-2,7-Dibenzyl-5-isopropyl-7,8-dihydro-1H,5H-imidazo[2,1-b]purin-4-one::CHEMBL370241

SMILES: CC(C)N1C2=N[C@H](Cc3ccccc3)CN2c2nc(Cc3ccccc3)[nH]c2C1=O

InChI Key: InChIKey=MTYOPXUDZJLFMU-LJQANCHMSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50165772   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50165772
PNG
((R)-2,7-Dibenzyl-5-isopropyl-7,8-dihydro-1H,5H-imi...)
Show SMILES CC(C)N1C2=N[C@H](Cc3ccccc3)CN2c2nc(Cc3ccccc3)[nH]c2C1=O
Show InChI InChI=1S/C24H25N5O/c1-16(2)29-23(30)21-22(27-20(26-21)14-18-11-7-4-8-12-18)28-15-19(25-24(28)29)13-17-9-5-3-6-10-17/h3-12,16,19H,13-15H2,1-2H3,(H,26,27)/t19-/m1/s1
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Similars

Article
PubMed
n/an/a 22n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human phosphodiesterase 5


Bioorg Med Chem Lett 15: 2365-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.02.083
BindingDB Entry DOI: 10.7270/Q2TM79MQ
More data for this
Ligand-Target Pair