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BDBM50165787 (R)-7-Benzyl-5-ethyl-3-(4-hydroxy-benzyl)-2-phenylethynyl-7,8-dihydro-3H,5H-imidazo[2,1-b]purin-4-one::CHEMBL365944

SMILES: CCN1C2=N[C@H](Cc3ccccc3)CN2c2nc(C#Cc3ccccc3)n(Cc3ccc(O)cc3)c2C1=O

InChI Key: InChIKey=DATBCDYXHPVZMS-RUZDIDTESA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50165787   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50165787
PNG
((R)-7-Benzyl-5-ethyl-3-(4-hydroxy-benzyl)-2-phenyl...)
Show SMILES CCN1C2=N[C@H](Cc3ccccc3)CN2c2nc(C#Cc3ccccc3)n(Cc3ccc(O)cc3)c2C1=O
Show InChI InChI=1S/C31H27N5O2/c1-2-34-30(38)28-29(36-21-25(32-31(34)36)19-23-11-7-4-8-12-23)33-27(18-15-22-9-5-3-6-10-22)35(28)20-24-13-16-26(37)17-14-24/h3-14,16-17,25,37H,2,19-21H2,1H3/t25-/m1/s1
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Similars

Article
PubMed
n/an/a 5.30n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human phosphodiesterase 5


Bioorg Med Chem Lett 15: 2365-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.02.083
BindingDB Entry DOI: 10.7270/Q2TM79MQ
More data for this
Ligand-Target Pair