BDBM50166908 5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca-2(11),3,5,7,9-pentaene; dihydrochloride::CHEMBL556954::US9993465, Varenicline::VARENICLINE

SMILES: C1C2CNCC1c1cc3nccnc3cc21

InChI Key: InChIKey=JQSHBVHOMNKWFT-UHFFFAOYSA-N

Data: 22 KI  9 IC50  8 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 39 hits for monomerid = 50166908   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ATP-binding cassette sub-family C member 3 (Human)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Human)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	0.0600	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Human)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	950	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Rat)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Rat)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	2.10E+4	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Human)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	94	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Human)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	94	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Human)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	950	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rat)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bile salt export pump (Human)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 2 (Human)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 4 (Human)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Human)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Human)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	38.9	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Rat)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	5.50E+4	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Human)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Human)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Human)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Human)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		0.110	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4 (Rat)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		0.120	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Human)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		0.120	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Human)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		0.130	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Human)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		0.295	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Human)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-2/beta-2 (Human)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		0.480	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-3/beta-2 (Rat)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		2.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rat)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		32.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rat)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		37	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-2/beta-4 (Rat)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		94	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rat)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		125	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Human)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		125	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Human)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		240	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rat)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rat)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		322	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Rat)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		390	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Rat)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		460	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Human)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		617	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Human)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		3.54E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Acetylcholine receptor subunit alpha/beta/delta/gamma (Pacific electric ray)	BDBM50166908 (CHEMBL556954 | VARENICLINE | 5,8,14-triazatetracyc...) Show SMILES Show InChI	GoogleScholar	UniChem		3.54E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair