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BDBM50166918 CHEMBL3798090

SMILES: Cn1c(cc2c(ncnc12)-c1ccc(NC(=O)C(C)(C)C)cc1)C(=O)OCc1ccccc1

InChI Key: InChIKey=FRXKDNXBGFMYCP-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50166918   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50166918
PNG
(CHEMBL3798090)
Show SMILES Cn1c(cc2c(ncnc12)-c1ccc(NC(=O)C(C)(C)C)cc1)C(=O)OCc1ccccc1
Show InChI InChI=1S/C26H26N4O3/c1-26(2,3)25(32)29-19-12-10-18(11-13-19)22-20-14-21(30(4)23(20)28-16-27-22)24(31)33-15-17-8-6-5-7-9-17/h5-14,16H,15H2,1-4H3,(H,29,32)
PDB

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Similars

Article
PubMed
n/an/a 786n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-tagged JAK2 expressed in baculovirus expression system using Z'-LYTE Try6 peptide as substrate incubated for 1 hr...


Bioorg Med Chem Lett 26: 2936-2941 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.027
BindingDB Entry DOI: 10.7270/Q2GB25ZS
More data for this
Ligand-Target Pair