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BDBM50166937 CHEMBL3800528

SMILES: Cn1c(cc2c(ncnc12)-c1ccc(NC(=O)c2ccccc2)cc1)C(=O)NCCCN1CCOCC1

InChI Key: InChIKey=FMBOOTWCGMYZLG-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50166937   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50166937
PNG
(CHEMBL3800528)
Show SMILES Cn1c(cc2c(ncnc12)-c1ccc(NC(=O)c2ccccc2)cc1)C(=O)NCCCN1CCOCC1
Show InChI InChI=1S/C28H30N6O3/c1-33-24(28(36)29-12-5-13-34-14-16-37-17-15-34)18-23-25(30-19-31-26(23)33)20-8-10-22(11-9-20)32-27(35)21-6-3-2-4-7-21/h2-4,6-11,18-19H,5,12-17H2,1H3,(H,29,36)(H,32,35)
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Similars

Article
PubMed
n/an/a 94n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human GST-tagged JAK2 expressed in baculovirus expression system using Z'-LYTE Try6 peptide as substrate incubated for 1 hr...


Bioorg Med Chem Lett 26: 2936-2941 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.027
BindingDB Entry DOI: 10.7270/Q2GB25ZS
More data for this
Ligand-Target Pair