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BDBM50166963 CHEMBL3797777

SMILES: Nc1cccnc1C(=O)Nc1ccc(N2CC(CC2=O)c2c(F)cccc2Cl)c(Cl)c1

InChI Key: InChIKey=SPXQSYJYZYXNHW-UHFFFAOYNA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50166963   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166963
PNG
(CHEMBL3797777)
Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2CC(CC2=O)c2c(F)cccc2Cl)c(Cl)c1
Show InChI InChI=1/C22H17Cl2FN4O2/c23-14-3-1-4-16(25)20(14)12-9-19(30)29(11-12)18-7-6-13(10-15(18)24)28-22(31)21-17(26)5-2-8-27-21/h1-8,10,12H,9,11,26H2,(H,28,31)
UniProtKB/SwissProt

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AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 1.90n/an/an/an/a



Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166963
PNG
(CHEMBL3797777)
Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2CC(CC2=O)c2c(F)cccc2Cl)c(Cl)c1
Show InChI InChI=1/C22H17Cl2FN4O2/c23-14-3-1-4-16(25)20(14)12-9-19(30)29(11-12)18-7-6-13(10-15(18)24)28-22(31)21-17(26)5-2-8-27-21/h1-8,10,12H,9,11,26H2,(H,28,31)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 1.86E+3n/an/an/an/a



Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)

More data for this
Ligand-Target Pair