BDBM50167490 4-{5-[4-(2-Methyl-quinolin-4-ylmethoxy)-phenyl]-2,4,6-trioxo-hexahydro-pyrimidin-5-yl}-piperazine-1-carboxylic acid tert-butyl ester::CHEMBL365386

SMILES Cc1cc(COc2ccc(cc2)C2(N3CCN(CC3)C(=O)OC(C)(C)C)C(=O)NC(=O)NC2=O)c2ccccc2n1

InChI Key InChIKey=MUEJBYPIDLKGKN-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50167490   

TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50167490(4-{5-[4-(2-Methyl-quinolin-4-ylmethoxy)-phenyl]-2,...)
Affinity DataKi: >2.13E+3nMAssay Description:In vitro binding affinity against matrix metalloprotease 9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50167490(4-{5-[4-(2-Methyl-quinolin-4-ylmethoxy)-phenyl]-2,...)
Affinity DataKi: >3.33E+3nMAssay Description:In vitro binding affinity against matrix metalloprotease 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50167490(4-{5-[4-(2-Methyl-quinolin-4-ylmethoxy)-phenyl]-2,...)
Affinity DataKi: >4.95E+3nMAssay Description:In vitro binding affinity against matrix metalloprotease 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50167490(4-{5-[4-(2-Methyl-quinolin-4-ylmethoxy)-phenyl]-2,...)
Affinity DataKi: >5.02E+3nMAssay Description:In vitro binding affinity against matrix metalloprotease 13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50167490(4-{5-[4-(2-Methyl-quinolin-4-ylmethoxy)-phenyl]-2,...)
Affinity DataIC50:  160nMAssay Description:In vitro inhibitory concentration against human tumor necrosis factor-alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed