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BDBM50167597 7-Thiophen-2-yl-6-p-tolyl-pyrido[2,3-d]pyrimidin-4-ylamine::CHEMBL193286

SMILES: Cc1ccc(cc1)-c1cc2c(N)ncnc2nc1-c1cccs1

InChI Key: InChIKey=WKNDFOXQMZFDQX-UHFFFAOYSA-N

Data: 2 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50167597   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Adenosine kinase


(Homo sapiens (Human))
BDBM50167597
PNG
(7-Thiophen-2-yl-6-p-tolyl-pyrido[2,3-d]pyrimidin-4...)
Show SMILES Cc1ccc(cc1)-c1cc2c(N)ncnc2nc1-c1cccs1
Show InChI InChI=1S/C18H14N4S/c1-11-4-6-12(7-5-11)13-9-14-17(19)20-10-21-18(14)22-16(13)15-3-2-8-23-15/h2-10H,1H3,(H2,19,20,21,22)
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PC sid
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Article
PubMed
n/an/a 800n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against Adenosine Kinase (intact cells)


Bioorg Med Chem Lett 15: 2803-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.098
BindingDB Entry DOI: 10.7270/Q2G160CH
More data for this
Ligand-Target Pair
Adenosine kinase


(Homo sapiens (Human))
BDBM50167597
PNG
(7-Thiophen-2-yl-6-p-tolyl-pyrido[2,3-d]pyrimidin-4...)
Show SMILES Cc1ccc(cc1)-c1cc2c(N)ncnc2nc1-c1cccs1
Show InChI InChI=1S/C18H14N4S/c1-11-4-6-12(7-5-11)13-9-14-17(19)20-10-21-18(14)22-16(13)15-3-2-8-23-15/h2-10H,1H3,(H2,19,20,21,22)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 9n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against Adenosine Kinase (enzyme)


Bioorg Med Chem Lett 15: 2803-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.098
BindingDB Entry DOI: 10.7270/Q2G160CH
More data for this
Ligand-Target Pair