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BDBM50168099 CHEMBL3798766

SMILES: COc1ccccc1Cn1cc2nc(nc(N)c2n1)-c1ccco1

InChI Key: InChIKey=AQMYJLYXFKJXMD-UHFFFAOYSA-N

Data: 3 KI  3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50168099   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Adenosine receptor A2a


(Homo sapiens (human))
BDBM50168099
PNG
(CHEMBL3798766)
Show SMILES COc1ccccc1Cn1cc2nc(nc(N)c2n1)-c1ccco1
Show InChI InChI=1S/C17H15N5O2/c1-23-13-6-3-2-5-11(13)9-22-10-12-15(21-22)16(18)20-17(19-12)14-7-4-8-24-14/h2-8,10H,9H2,1H3,(H2,18,19,20)
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Article
PubMed
5.40n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Displacement of [3H]-ZM241385 from human adenosine A2A receptor expressed in CHO cell membranes after 60 mins by scintillation counting method


Bioorg Med Chem 24: 2794-808 (2016)


Article DOI: 10.1016/j.bmc.2016.04.048
BindingDB Entry DOI: 10.7270/Q23X88JC
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (human))
BDBM50168099
PNG
(CHEMBL3798766)
Show SMILES COc1ccccc1Cn1cc2nc(nc(N)c2n1)-c1ccco1
Show InChI InChI=1S/C17H15N5O2/c1-23-13-6-3-2-5-11(13)9-22-10-12-15(21-22)16(18)20-17(19-12)14-7-4-8-24-14/h2-8,10H,9H2,1H3,(H2,18,19,20)
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PubMed
98n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Displacement of [3H]-DPCPX from human adenosine A1 receptor expressed in CHO cell membranes after 120 mins by scintillation counting method


Bioorg Med Chem 24: 2794-808 (2016)


Article DOI: 10.1016/j.bmc.2016.04.048
BindingDB Entry DOI: 10.7270/Q23X88JC
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50168099
PNG
(CHEMBL3798766)
Show SMILES COc1ccccc1Cn1cc2nc(nc(N)c2n1)-c1ccco1
Show InChI InChI=1S/C17H15N5O2/c1-23-13-6-3-2-5-11(13)9-22-10-12-15(21-22)16(18)20-17(19-12)14-7-4-8-24-14/h2-8,10H,9H2,1H3,(H2,18,19,20)
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PubMed
196n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Displacement of [125I]-AB-MECA from human adenosine A3 receptor expressed in CHO cell membranes after 60 mins by scintillation counting method


Bioorg Med Chem 24: 2794-808 (2016)


Article DOI: 10.1016/j.bmc.2016.04.048
BindingDB Entry DOI: 10.7270/Q23X88JC
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (human))
BDBM50168099
PNG
(CHEMBL3798766)
Show SMILES COc1ccccc1Cn1cc2nc(nc(N)c2n1)-c1ccco1
Show InChI InChI=1S/C17H15N5O2/c1-23-13-6-3-2-5-11(13)9-22-10-12-15(21-22)16(18)20-17(19-12)14-7-4-8-24-14/h2-8,10H,9H2,1H3,(H2,18,19,20)
PDB

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Article
PubMed
n/an/a 106n/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Antagonist activity at human adenosine A1 receptor expressed in CHO cell membranes assessed as suppression of CCPA-mediated inhibition of cAMP level ...


Bioorg Med Chem 24: 2794-808 (2016)


Article DOI: 10.1016/j.bmc.2016.04.048
BindingDB Entry DOI: 10.7270/Q23X88JC
More data for this
Ligand-Target Pair
Adenosine receptor A2b


(Homo sapiens (Human))
BDBM50168099
PNG
(CHEMBL3798766)
Show SMILES COc1ccccc1Cn1cc2nc(nc(N)c2n1)-c1ccco1
Show InChI InChI=1S/C17H15N5O2/c1-23-13-6-3-2-5-11(13)9-22-10-12-15(21-22)16(18)20-17(19-12)14-7-4-8-24-14/h2-8,10H,9H2,1H3,(H2,18,19,20)
NCI pathway
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UniChem

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Article
PubMed
n/an/a 512n/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Antagonist activity at human adenosine A2B receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated...


Bioorg Med Chem 24: 2794-808 (2016)


Article DOI: 10.1016/j.bmc.2016.04.048
BindingDB Entry DOI: 10.7270/Q23X88JC
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (human))
BDBM50168099
PNG
(CHEMBL3798766)
Show SMILES COc1ccccc1Cn1cc2nc(nc(N)c2n1)-c1ccco1
Show InChI InChI=1S/C17H15N5O2/c1-23-13-6-3-2-5-11(13)9-22-10-12-15(21-22)16(18)20-17(19-12)14-7-4-8-24-14/h2-8,10H,9H2,1H3,(H2,18,19,20)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

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GoogleScholar
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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.20n/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Antagonist activity at human adenosine A2A receptor expressed in CHO cell membranes assessed as inhibition of NECA-stimulated cAMP level preincubated...


Bioorg Med Chem 24: 2794-808 (2016)


Article DOI: 10.1016/j.bmc.2016.04.048
BindingDB Entry DOI: 10.7270/Q23X88JC
More data for this
Ligand-Target Pair