BDBM50168694 1-((R)-2-Amino-2-phenyl-ethyl)-3-(2-bromo-6-fluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-[1,3,5]triazinane-2,4,6-trione::CHEMBL368511

SMILES COc1cccc(c1F)-n1c(=O)n(C[C@H](N)c2ccccc2)c(=O)n(Cc2c(F)cccc2Br)c1=O

InChI Key InChIKey=JPJCBKFCBLFFDG-IBGZPJMESA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50168694   

TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168694(1-((R)-2-Amino-2-phenyl-ethyl)-3-(2-bromo-6-fluoro...)
Affinity DataKi:  2nMAssay Description:In vitro ability to inhibit des-Gly[125I-Tyr, DLeu, NMeLeu,Pro-NEt]-GnRH radioligand binding to the cloned human GnRH receptor stably expressed in HE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168694(1-((R)-2-Amino-2-phenyl-ethyl)-3-(2-bromo-6-fluoro...)
Affinity DataKi:  24nMAssay Description:Inhibition constant against monkey GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168694(1-((R)-2-Amino-2-phenyl-ethyl)-3-(2-bromo-6-fluoro...)
Affinity DataKi:  2.30E+3nMAssay Description:Inhibition constant against rat GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168694(1-((R)-2-Amino-2-phenyl-ethyl)-3-(2-bromo-6-fluoro...)
Affinity DataIC50:  33nMAssay Description:Inhibition of human GnRH receptor stimulated inositol phosphate accumulation in RBL cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed