BDBM50168789 3-[1-(4-Chloro-benzyl)-3-methyl-1H-indol-2-yl]-2,2-dimethyl-propionic acid::CHEMBL555147

SMILES Cc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccccc12

InChI Key InChIKey=LKVQGUGNUBMCCE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50168789   

TargetProstaglandin E synthase(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50168789(3-[1-(4-Chloro-benzyl)-3-methyl-1H-indol-2-yl]-2,2...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of microsomal PGESMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50168789(3-[1-(4-Chloro-benzyl)-3-methyl-1H-indol-2-yl]-2,2...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of human recombinant microsomal PGES-1 expressed in freestyle 293-f cells assessed as conversion of PGH2 to PGE2 after 15 mins by enzyme i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetProstaglandin E synthase 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168789(3-[1-(4-Chloro-benzyl)-3-methyl-1H-indol-2-yl]-2,2...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed