BDBM50169442 (1R,4S,6R)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide::CHEMBL364346
SMILES CN1C[C@H]2CC[C@@H]1[C@@H](C2)C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N1CCC(CC1)(C1CCCCC1)C(=O)NC(C)(C)C
InChI Key InChIKey=ARFBDECCXOFCBN-HOLBEBDISA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 18 hits for monomerid = 50169442
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataEC50: 1.60E+5nMAssay Description:Effective concentration (binding affinity) exhibited against human melanocortin receptor 1 by radio labeled ligand assay (Displacement of [125I]-NDP-...More data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 7.50E+5nMAssay Description:Inhibition concentration (binding affinity) against human melanocortin receptor 1 by displacement of [125I]NDP-alpha-MSH from the human receptors exp...More data for this Ligand-Target Pair
Affinity DataEC50: 6.00E+3nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation in mouse melanocortin receptor (mMC4R)More data for this Ligand-Target Pair
Affinity DataEC50: 1.10E+4nMAssay Description:Effective concentration (binding affinity) exhibited against human melanocortin receptor 4 by radio labeled ligand assay (Displacement of [125I]-NDP-...More data for this Ligand-Target Pair
Affinity DataEC50: 8.50E+5nMAssay Description:Effective concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]-NDP-...More data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataEC50: 1.60E+5nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation in human melanocortin receptor (hMC1R)More data for this Ligand-Target Pair
Affinity DataEC50: 5.00E+3nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation in rat melanocortin receptor (rMC4R)More data for this Ligand-Target Pair
Affinity DataEC50: 1.10E+4nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation in dog melanocortin receptor (dMC4R)More data for this Ligand-Target Pair
Affinity DataEC50: 1.10E+4nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation in human melanocortin receptor (hMC4R)More data for this Ligand-Target Pair
Affinity DataEC50: 8.50E+5nMAssay Description:Concentration of compound at 50% maximum cAMP accumulation in human melanocortin receptor (hMC5R)More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition concentration (binding affinity) against human melanocortin receptor 4 by displacement of [125I]-NDP-alpha-MSH from the human receptors ex...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition concentration (binding affinity) against mouse melanocortin receptor 4 by displacement of [125I]-NDP-alpha-MSH from the human receptors ex...More data for this Ligand-Target Pair
Affinity DataIC50: 9.45E+5nMAssay Description:Inhibition concentration (binding affinity) against human melanocortin receptor 5 by displacement of [125I]NDP-alpha-MSH from the human receptors exp...More data for this Ligand-Target Pair
TargetAdrenocorticotropic hormone receptor(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition concentration (binding affinity) against human melanocortin receptor 2 by displacement of [125I]NDP-alpha-MSH from the human receptors exp...More data for this Ligand-Target Pair
Affinity DataEC50: 8.50E+5nMAssay Description:Effective concentration (binding affinity) exhibited against human melanocortin receptor 5 by radio labeled ligand assay (Displacement of [125I]-NDP-...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition concentration (binding affinity) against rat melanocortin receptor 4 by displacement of [125I]-NDP-alpha-MSH from the human receptors expr...More data for this Ligand-Target Pair
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition concentration (binding affinity) against dog melanocortin receptor 4 by displacement of [125I]-NDP-alpha-MSH from the human receptors expr...More data for this Ligand-Target Pair
Affinity DataIC50: 9.42E+5nMAssay Description:Inhibition concentration (binding affinity) against human melanocortin receptor 3 by displacement of [125I]NDP-alpha-MSH from the human receptors exp...More data for this Ligand-Target Pair