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BDBM50169685 CHEMBL360353::N-[4-(Thiazol-2-ylcarbamoyl)-thiazol-5-yl]-malonamic acid ethyl ester

SMILES: CCOC(=O)CC(=O)Nc1scnc1C(=O)Nc1nccs1

InChI Key: InChIKey=OOUWLDLZLGDRQA-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50169685   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50169685
PNG
(CHEMBL360353 | N-[4-(Thiazol-2-ylcarbamoyl)-thiazo...)
Show SMILES CCOC(=O)CC(=O)Nc1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C12H12N4O4S2/c1-2-20-8(18)5-7(17)15-11-9(14-6-22-11)10(19)16-12-13-3-4-21-12/h3-4,6H,2,5H2,1H3,(H,15,17)(H,13,16,19)
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KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 670n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Saccharomyces cerevisiae MetAP1 (330 nM)


Bioorg Med Chem Lett 15: 3732-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.055
BindingDB Entry DOI: 10.7270/Q2T1534B
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50169685
PNG
(CHEMBL360353 | N-[4-(Thiazol-2-ylcarbamoyl)-thiazo...)
Show SMILES CCOC(=O)CC(=O)Nc1scnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C12H12N4O4S2/c1-2-20-8(18)5-7(17)15-11-9(14-6-22-11)10(19)16-12-13-3-4-21-12/h3-4,6H,2,5H2,1H3,(H,15,17)(H,13,16,19)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 66n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Escherichia coli MetAP1 (150 nM)


Bioorg Med Chem Lett 15: 3732-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.055
BindingDB Entry DOI: 10.7270/Q2T1534B
More data for this
Ligand-Target Pair