BDBM50169959 2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin-3-yl)ethylamino)pyrimidin-4-yl)acetonitrile::AS-601245::AS601245::CHEMBL1788116::CHEMBL191384::[3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-ethylamino)-pyrimidin-4-yl]-acetonitrile

SMILES: c1ccc2c(c1)nc(s2)C(C#N)c3ccnc(n3)NCCc4cccnc4

InChI Key: InChIKey=RCYPVQCPYKNSTG-UHFFFAOYSA-N

Data: 48 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 48 hits for monomerid = 50169959   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-activated protein kinase 2 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Ribosomal protein S6 kinase alpha-3 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Epidermal growth factor receptor (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 6 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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MAP kinase-activated protein kinase 5 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Inhibitor of nuclear factor kappa-B kinase subunit beta (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Mitogen-activated protein kinase 3 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Mitogen-activated protein kinase 10 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Dual specificity mitogen-activated protein kinase kinase 7 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 4 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Tyrosine-protein kinase Blk (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Mitogen-activated protein kinase 10 (Rat)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 9 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 9 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Glycogen synthase kinase-3 beta (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Serine/threonine-protein kinase pim-1 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 9 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 9 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 9 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Protein kinase C alpha type (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase beta-1/beta-2 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Rho-associated protein kinase 2 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 9 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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3-phosphoinositide-dependent protein kinase 1 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Sgk1 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase 14 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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RAC-alpha serine/threonine-protein kinase (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Ribosomal protein S6 kinase alpha-5 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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RAF proto-oncogene serine/threonine-protein kinase (Human)	BDBM50169959 ([3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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