BDBM50171514 2-Chloro-N-[4-(4,5-dichloro-2-fluoro-phenylamino)-quinazolin-6-yl]-acetamide::CHEMBL275762
SMILES Fc1cc(Cl)c(Cl)cc1Nc1ncnc2ccc(NC(=O)CCl)cc12
InChI Key InChIKey=VBXDUSMRNQVJRO-UHFFFAOYSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50171514
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hadassah Hebrew University
Curated by ChEMBL
Hadassah Hebrew University
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of EGF Receptor autophosphorylation in A431 cell lysate; Range = 5-25 nMMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hadassah Hebrew University
Curated by ChEMBL
Hadassah Hebrew University
Curated by ChEMBL
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of EGF Receptor autophosphorylation in A431 cell lysateMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hadassah Hebrew University
Curated by ChEMBL
Hadassah Hebrew University
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of HER1 kinase in intact DHER14 cells; Range = 5-15 nMMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Hadassah Hebrew University
Curated by ChEMBL
Hadassah Hebrew University
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of HER2 kinase in intact CSH12 cells; Range = 25-50 nMMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Hadassah Hebrew University
Curated by ChEMBL
Hadassah Hebrew University
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human PDGFR kinase in intact NIHPDGFR cellsMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hadassah Hebrew University
Curated by ChEMBL
Hadassah Hebrew University
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of EGF Receptor autophosphorylation in A431 cell lysate; Range = 25-50 nMMore data for this Ligand-Target Pair