BDBM50171514 2-Chloro-N-[4-(4,5-dichloro-2-fluoro-phenylamino)-quinazolin-6-yl]-acetamide::CHEMBL275762

SMILES Fc1cc(Cl)c(Cl)cc1Nc1ncnc2ccc(NC(=O)CCl)cc12

InChI Key InChIKey=VBXDUSMRNQVJRO-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50171514   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hadassah Hebrew University

Curated by ChEMBL
LigandPNGBDBM50171514(2-Chloro-N-[4-(4,5-dichloro-2-fluoro-phenylamino)-...)
Affinity DataIC50:  25nMAssay Description:Inhibition of EGF Receptor autophosphorylation in A431 cell lysate; Range = 5-25 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hadassah Hebrew University

Curated by ChEMBL
LigandPNGBDBM50171514(2-Chloro-N-[4-(4,5-dichloro-2-fluoro-phenylamino)-...)
Affinity DataIC50:  0.0700nMAssay Description:Inhibition of EGF Receptor autophosphorylation in A431 cell lysateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hadassah Hebrew University

Curated by ChEMBL
LigandPNGBDBM50171514(2-Chloro-N-[4-(4,5-dichloro-2-fluoro-phenylamino)-...)
Affinity DataIC50:  15nMAssay Description:Inhibition of HER1 kinase in intact DHER14 cells; Range = 5-15 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Hadassah Hebrew University

Curated by ChEMBL
LigandPNGBDBM50171514(2-Chloro-N-[4-(4,5-dichloro-2-fluoro-phenylamino)-...)
Affinity DataIC50:  50nMAssay Description:Inhibition of HER2 kinase in intact CSH12 cells; Range = 25-50 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Hadassah Hebrew University

Curated by ChEMBL
LigandPNGBDBM50171514(2-Chloro-N-[4-(4,5-dichloro-2-fluoro-phenylamino)-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human PDGFR kinase in intact NIHPDGFR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hadassah Hebrew University

Curated by ChEMBL
LigandPNGBDBM50171514(2-Chloro-N-[4-(4,5-dichloro-2-fluoro-phenylamino)-...)
Affinity DataIC50:  25nMAssay Description:Inhibition of EGF Receptor autophosphorylation in A431 cell lysate; Range = 25-50 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed