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BDBM50173303 CHEMBL3809560

SMILES: Cn1cnc(Cn2nc3ccc(cn3c2=O)-c2ccc(OC(F)(F)F)cc2)n1

InChI Key: InChIKey=PKMGMZYOIJAWBK-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50173303   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM50173303
PNG
(CHEMBL3809560)
Show SMILES Cn1cnc(Cn2nc3ccc(cn3c2=O)-c2ccc(OC(F)(F)F)cc2)n1
Show InChI InChI=1S/C17H13F3N6O2/c1-24-10-21-14(22-24)9-26-16(27)25-8-12(4-7-15(25)23-26)11-2-5-13(6-3-11)28-17(18,19)20/h2-8,10H,9H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Gilead Sciences Inc

Curated by ChEMBL


Assay Description
Inhibition of 0.1 Hz stimulated human Nav1.5alpha expressed in HEK293 cells assessed as inhibition of late sodium current with 3 compound additions f...


Bioorg Med Chem Lett 26: 3207-11 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.096
BindingDB Entry DOI: 10.7270/Q2PG1TNG
More data for this
Ligand-Target Pair