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BDBM50173375 CHEMBL3810248

SMILES: C[Si](C)(C)c1ccc(cc1)-c1ccc2nnc(n2c1)C(F)(F)F

InChI Key: InChIKey=ACRMMCGSOUYBCS-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50173375   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM50173375
PNG
(CHEMBL3810248)
Show SMILES C[Si](C)(C)c1ccc(cc1)-c1ccc2nnc(n2c1)C(F)(F)F
Show InChI InChI=1S/C16H16F3N3Si/c1-23(2,3)13-7-4-11(5-8-13)12-6-9-14-20-21-15(16(17,18)19)22(14)10-12/h4-10H,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 59n/an/an/an/an/an/a



Gilead Sciences Inc

Curated by ChEMBL


Assay Description
Inhibition of Nav 1.5 (unknown origin) assessed as reduction in late channel current


Bioorg Med Chem Lett 26: 3202-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.101
BindingDB Entry DOI: 10.7270/Q21R6SDP
More data for this
Ligand-Target Pair