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BDBM50173619 CHEMBL425909::N-{4-[2-Ethyl-4-(4-fluoro-phenyl)-thiazol-5-yl]-pyridin-2-yl}-benzamide

SMILES: CCc1nc(c(s1)-c1ccnc(NC(=O)c2ccccc2)c1)-c1ccc(F)cc1

InChI Key: InChIKey=ZOFLBKLKRCZRFS-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50173619   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine D2 receptor and serotonin 2a receptor


(Homo sapiens (Human))
BDBM50173619
PNG
(CHEMBL425909 | N-{4-[2-Ethyl-4-(4-fluoro-phenyl)-t...)
Show SMILES CCc1nc(c(s1)-c1ccnc(NC(=O)c2ccccc2)c1)-c1ccc(F)cc1
Show InChI InChI=1S/C23H18FN3OS/c1-2-20-27-21(15-8-10-18(24)11-9-15)22(29-20)17-12-13-25-19(14-17)26-23(28)16-6-4-3-5-7-16/h3-14H,2H2,1H3,(H,25,26,28)
MMDB

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Article
PubMed
n/an/a 31n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against mitogen-activated protein kinase p38 alpha


J Med Chem 48: 5966-79 (2005)


Article DOI: 10.1021/jm050165o
BindingDB Entry DOI: 10.7270/Q2G160DZ
More data for this
Ligand-Target Pair