BDBM50173844 4-(3-chloro-4-fluorophenylamino)-6-(2-morpholino-1-phenylethylamino)-1,7-naphthyridine-3-carbonitrile::CHEMBL196919

SMILES Fc1ccc(Nc2c(cnc3cnc(NC(CN4CCOCC4)c4ccccc4)cc23)C#N)cc1Cl

InChI Key InChIKey=BOMGEFCTGNMKPY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50173844   

TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173844(4-(3-chloro-4-fluorophenylamino)-6-(2-morpholino-1...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed