BDBM50174705 (R)-N-(6-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-3-oxoprop-1-enyl)quinolin-7-yl)acetamide::CHEMBL199412

SMILES C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)\C=C\c1cc2cccnc2cc1NC(C)=O

InChI Key InChIKey=MVIVWOSZVYNMQN-RUJXFNLJSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50174705   

TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174705((R)-N-(6-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50:  300nMAssay Description:Antagonistic activity at rat CCR1 in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174705((R)-N-(6-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50:  20nMAssay Description:Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174705((R)-N-(6-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Antagonistic activity at mouse CCR1 in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174705((R)-N-(6-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50:  30nMAssay Description:Antagonistic activity at human CCR1 in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed