BDBM50175755 2-(4-(5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-2-oxo-1,2-dihydroquinolin-7-yl)piperidin-1-yl)-2-methylpropanoic acid::CHEMBL200047

SMILES CC(C)(N1CCC(CC1)c1cc(-c2ccc(F)cc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1)C(O)=O

InChI Key InChIKey=RMAKFNMXUQPJOV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50175755   

TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50175755(2-(4-(5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorop...)
Affinity DataIC50: 0.840nMAssay Description:Inhibition of P38 alpha MAPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50175755(2-(4-(5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorop...)
Affinity DataIC50: 3.75nMAssay Description:Inhibition of TNF alpha release in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50175755(2-(4-(5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorop...)
Affinity DataIC50: 79.1nMAssay Description:Inhibition of LPS stimulated TNF alpha release in whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed