BDBM50176377 (R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)nicotinamide::CHEMBL204449

SMILES: C[C@@H](NC(=O)c1cccnc1Oc1ccc(F)cc1)c1cccs1

InChI Key: InChIKey=LRQBXHMVEXEFBO-UHFFFAOYSA-N

Data: 17 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50176377   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Human)	BDBM50176377 ((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	107	n/a	n/a	n/a	n/a	n/a	n/a
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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Human)	BDBM50176377 ((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM50176377 ((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
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High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (Human)	BDBM50176377 ((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
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cGMP-dependent 3',5'-cyclic phosphodiesterase (Human)	BDBM50176377 ((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Human)	BDBM50176377 ((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	925	n/a	n/a	n/a	n/a	n/a	n/a
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High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (Human)	BDBM50176377 ((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Human)	BDBM50176377 ((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
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cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Human)	BDBM50176377 ((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.38E+3	n/a	n/a	n/a	n/a	n/a	n/a
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM50176377 ((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM50176377 ((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Human)	BDBM50176377 ((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	185	n/a	n/a	n/a	n/a	n/a	n/a
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cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B (Human)	BDBM50176377 ((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM50176377 ((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM50176377 ((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM50176377 ((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Human)	BDBM50176377 ((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	22	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Human)	BDBM50176377 ((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
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