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BDBM50176973 CHEMBL3814827

SMILES: FC(F)(F)c1ccc(OC(CCNCc2ccccn2)c2ccccc2)cc1

InChI Key: InChIKey=GQULUVWAOIVUQB-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50176973   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50176973
PNG
(CHEMBL3814827)
Show SMILES FC(F)(F)c1ccc(OC(CCNCc2ccccn2)c2ccccc2)cc1
Show InChI InChI=1S/C22H21F3N2O/c23-22(24,25)18-9-11-20(12-10-18)28-21(17-6-2-1-3-7-17)13-15-26-16-19-8-4-5-14-27-19/h1-12,14,21,26H,13,15-16H2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 50n/an/an/an/an/an/a



Swiss Federal Institute of Technology (ETH)

Curated by ChEMBL


Assay Description
Inhibition of inactivated PLK1 in human HeLa cells using casein as substrate by immunoprecipitation assay


J Med Chem 59: 4077-86 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01849
BindingDB Entry DOI: 10.7270/Q2FN184P
More data for this
Ligand-Target Pair