BDBM50177716 CHEMBL3813873::US11679110, Compound Pexidartinib::US20230382871, Compound PLX3397

SMILES: c1cc(ncc1Cc2c[nH]c3c2cc(cn3)Cl)NCc4ccc(nc4)C(F)(F)F

InChI Key: InChIKey=JGWRKYUXBBNENE-UHFFFAOYSA-N

Data: 54 IC50  4 Kd

PDB links: 2 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 88 hits for monomerid = 50177716   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	117	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	351	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	359	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.14E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	5.80	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	890	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	860	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	880	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	643	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Human)	BDBM50177716 (CHEMBL3813873 | US11679110, Compound Pexidartinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair