BDBM50177813 2-(4-Ethylpiperazin-1-yl)-5-{[6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino}benzo-1,4-quinone::CHEMBL200818

SMILES CCN1CCN(CC1)C1=CC(=O)C(Nc2ncnc3cc(OCCOC)c(OC)cc23)=CC1=O

InChI Key InChIKey=VZJKXXJUTFHHOB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50177813   

TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177813(2-(4-Ethylpiperazin-1-yl)-5-{[6-methoxy-7-(2-metho...)
Affinity DataIC50: 133nMAssay Description:Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177813(2-(4-Ethylpiperazin-1-yl)-5-{[6-methoxy-7-(2-metho...)
Affinity DataIC50: 271nMAssay Description:Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 100 uM glutathioneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177813(2-(4-Ethylpiperazin-1-yl)-5-{[6-methoxy-7-(2-metho...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 5% mouse plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177813(2-(4-Ethylpiperazin-1-yl)-5-{[6-methoxy-7-(2-metho...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against VEGF stimulated autophosphorylation of VEGFR2 expressed in KDR15 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed