BDBM50177826 2-{[6-Methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino}-5-(2-methylaziridin-1-yl)benzo-1,4-quinone::CHEMBL200633

SMILES COCCOc1cc2ncnc(N=C3CC(=O)C(=CC3=O)N3CC3C)c2cc1OC

InChI Key InChIKey=CTZXABOEDHPWHE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50177826   

TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177826(2-{[6-Methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]a...)
Affinity DataIC50: 206nMAssay Description:Inhibitory activity against VEGF stimulated autophosphorylation of VEGFR2 expressed in KDR15 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177826(2-{[6-Methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]a...)
Affinity DataIC50: 540nMAssay Description:Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177826(2-{[6-Methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]a...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed