BDBM50177842 2-{[6-Methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-yl]amino}-5-[(1-methylprop-2-yn-1-yl)oxy]benzo-1,4-quinone::CHEMBL197071

SMILES COc1cc2c(N=C3CC(=O)C(OC(C)C#C)=CC3=O)ncnc2cc1OCCCN1CCCC1

InChI Key InChIKey=WJJULDAMDZDHRG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50177842   

TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177842(2-{[6-Methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazol...)
Affinity DataIC50: 30nMAssay Description:Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 5% mouse plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177842(2-{[6-Methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazol...)
Affinity DataIC50: 36nMAssay Description:Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177842(2-{[6-Methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazol...)
Affinity DataIC50: 42nMAssay Description:Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed