BDBM50177847 2-Methoxy-5-({6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-yl}amino)benzo-1,4-quinone::CHEMBL200723

SMILES COC1=CC(=O)C(Nc2ncnc3cc(OCC4CCN(C)CC4)c(OC)cc23)=CC1=O

InChI Key InChIKey=XMTZJEZOKDYHFG-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50177847   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177847(2-Methoxy-5-({6-methoxy-7-[(1-methylpiperidin-4-yl...)
Affinity DataIC50:  130nMAssay Description:Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 5% mouse plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177847(2-Methoxy-5-({6-methoxy-7-[(1-methylpiperidin-4-yl...)
Affinity DataIC50:  3.02E+3nMAssay Description:Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 1 mm ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177847(2-Methoxy-5-({6-methoxy-7-[(1-methylpiperidin-4-yl...)
Affinity DataIC50:  239nMAssay Description:Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177847(2-Methoxy-5-({6-methoxy-7-[(1-methylpiperidin-4-yl...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against VEGF stimulated autophosphorylation of VEGFR2 expressed in KDR15 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177847(2-Methoxy-5-({6-methoxy-7-[(1-methylpiperidin-4-yl...)
Affinity DataIC50:  240nMAssay Description:Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 100 uM glutathioneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed