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BDBM50177959 2-cyano-N-{3-[2-cyano-3-(4-methoxyphenyl)acryloylamino]propyl}-3-(4-methoxyphenyl)acrylamide::CHEMBL198787

SMILES: COc1ccc(\C=C(/C#N)C(=O)NCCCNC(=O)C(=C\c2ccc(OC)cc2)\C#N)cc1

InChI Key: InChIKey=BEQGWORDWFGHGC-OZNQKUEASA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50177959   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dynamin-1


(Homo sapiens (Human))
BDBM50177959
PNG
(2-cyano-N-{3-[2-cyano-3-(4-methoxyphenyl)acryloyla...)
Show SMILES COc1ccc(\C=C(/C#N)C(=O)NCCCNC(=O)C(=C\c2ccc(OC)cc2)\C#N)cc1
Show InChI InChI=1S/C25H24N4O4/c1-32-22-8-4-18(5-9-22)14-20(16-26)24(30)28-12-3-13-29-25(31)21(17-27)15-19-6-10-23(33-2)11-7-19/h4-11,14-15H,3,12-13H2,1-2H3,(H,28,30)(H,29,31)/b20-14+,21-15+
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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibitory activity against dynamin1 GTPase expressed in sheep brain


J Med Chem 48: 7781-8 (2005)


Article DOI: 10.1021/jm040208l
BindingDB Entry DOI: 10.7270/Q2BC3Z41
More data for this
Ligand-Target Pair