BDBM50178291 CHEMBL3814140

SMILES CCc1cc(nc(N)n1)-c1c[nH]c2ncc(cc12)-c1cnn(c1)C1CCNCC1

InChI Key InChIKey=USULOOHPZFLJHY-UHFFFAOYSA-N

Data  3 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50178291   

Target3-phosphoinositide-dependent protein kinase 1(Human)
Merck

Curated by ChEMBL

LigandBDBM50178291(CHEMBL3814140)Copy SMILESCopy InChI

Affinity DataIC50: 58nMAssay Description:Inhibition of human His6-tagged PDK1 using biotinylated PDKtide as substrate after 60 mins by topcount methodMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/18/2017
Entry Details Article
Copy BDB DOIPubMed
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Merck

Curated by ChEMBL

LigandBDBM50178291(CHEMBL3814140)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI3K gamma (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/18/2017
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

Target3-phosphoinositide-dependent protein kinase 1(Human)
Merck

Curated by ChEMBL

LigandBDBM50178291(CHEMBL3814140)Copy SMILESCopy InChI

Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of PDK1 in human PC3 cells assessed as reduction in AKT Thr308 phosphorylation after 45 minsMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
9/18/2017
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL