BDBM50178766 2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxamide::2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxylic acid amide::CHEMBL446446

SMILES NC(=O)C1CCCCc2c1[nH]c1ccc(Cl)cc21

InChI Key InChIKey=ABIVOOWWGYJNLV-UHFFFAOYSA-N

Data  7 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50178766   

TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
Elixir Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178766(2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory activity against pig brain NAD glycohydrolase (NADase) by radiochemical Nicotinamide release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Elixir Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178766(2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole...)
Affinity DataIC50:  652nMAssay Description:Inhibitory activity against human SIRT1 by radiochemical Nicotinamide release assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Elixir Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178766(2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole...)
Affinity DataIC50:  124nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Elixir Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178766(2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole...)
Affinity DataIC50:  180nMAssay Description:Inhibition of human full length SIRT1 expressed in DE3 cells by fluorimetric assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Elixir Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178766(2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole...)
Affinity DataIC50:  2.77E+3nMAssay Description:Inhibitory activity against recombinant human SIRT2 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase HST2(Saccharomyces cerevisiae)
Institute

Curated by ChEMBL
LigandPNGBDBM50178766(2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of yeast Hst2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Elixir Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178766(2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory activity against recombinant human SIRT3 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed