BDBM50178970 6-(4-hydroxy-3-isopropylphenoxy)-5,7-dimethylquinoline-2-carboxylic acid::CHEMBL203555

SMILES CC(C)c1cc(Oc2c(C)cc3nc(ccc3c2C)C(O)=O)ccc1O

InChI Key InChIKey=QFHPGLKTTMRBBJ-UHFFFAOYSA-N

Data  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50178970   

TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Karo Bio

Curated by ChEMBL
LigandPNGBDBM50178970(6-(4-hydroxy-3-isopropylphenoxy)-5,7-dimethylquino...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human TRalpha1 by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Karo Bio

Curated by ChEMBL
LigandPNGBDBM50178970(6-(4-hydroxy-3-isopropylphenoxy)-5,7-dimethylquino...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human TRbeta1 by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Karo Bio

Curated by ChEMBL
LigandPNGBDBM50178970(6-(4-hydroxy-3-isopropylphenoxy)-5,7-dimethylquino...)
Affinity DataIC50:  200nMAssay Description:Inhibition of thyroid hormone receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Karo Bio

Curated by ChEMBL
LigandPNGBDBM50178970(6-(4-hydroxy-3-isopropylphenoxy)-5,7-dimethylquino...)
Affinity DataEC50:  83nMAssay Description:Efficacy against TRAF-alpha-1 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Karo Bio

Curated by ChEMBL
LigandPNGBDBM50178970(6-(4-hydroxy-3-isopropylphenoxy)-5,7-dimethylquino...)
Affinity DataIC50:  15.1nMAssay Description:Inhibition of thyroid hormone receptor betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Karo Bio

Curated by ChEMBL
LigandPNGBDBM50178970(6-(4-hydroxy-3-isopropylphenoxy)-5,7-dimethylquino...)
Affinity DataEC50:  49nMAssay Description:Efficacy against TRAF-beta-1 reporter cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed