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BDBM50179487 3-(5-(benzo[d][1,3]dioxol-5-ylamino)-1,3,4-oxadiazol-2-yl)-N-(pyridin-3-ylmethyl)pyridin-2-amine::CHEMBL382359

SMILES: C(Nc1ncccc1-c1nnc(Nc2ccc3OCOc3c2)o1)c1cccnc1

InChI Key: InChIKey=DWTQAMVPEXBCOK-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50179487   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50179487
PNG
(3-(5-(benzo[d][1,3]dioxol-5-ylamino)-1,3,4-oxadiaz...)
Show SMILES C(Nc1ncccc1-c1nnc(Nc2ccc3OCOc3c2)o1)c1cccnc1
Show InChI InChI=1S/C20H16N6O3/c1-3-13(10-21-7-1)11-23-18-15(4-2-8-22-18)19-25-26-20(29-19)24-14-5-6-16-17(9-14)28-12-27-16/h1-10H,11-12H2,(H,22,23)(H,24,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of VEGFR-2 kinase assessed as phosphorylated level of pGAT-biotin peptide preincubated for 5 to 10 mins before addtion of substrate measur...


ACS Med Chem Lett 1: 488-492 (2010)


Article DOI: 10.1021/ml1001568
BindingDB Entry DOI: 10.7270/Q2NZ87ZN
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50179487
PNG
(3-(5-(benzo[d][1,3]dioxol-5-ylamino)-1,3,4-oxadiaz...)
Show SMILES C(Nc1ncccc1-c1nnc(Nc2ccc3OCOc3c2)o1)c1cccnc1
Show InChI InChI=1S/C20H16N6O3/c1-3-13(10-21-7-1)11-23-18-15(4-2-8-22-18)19-25-26-20(29-19)24-14-5-6-16-17(9-14)28-12-27-16/h1-10H,11-12H2,(H,22,23)(H,24,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 expressed HEK293 cells


ACS Med Chem Lett 1: 488-492 (2010)


Article DOI: 10.1021/ml1001568
BindingDB Entry DOI: 10.7270/Q2NZ87ZN
More data for this
Ligand-Target Pair