BindingDB logo
myBDB logout

BDBM50180146 (3S,5S)-2-aza-bicyclo[2.2.1]heptane-3,5-dicarboxylic acid::CHEMBL199331

SMILES: OC(=O)[C@H]1CC2CC1[C@H](N2)C(O)=O

InChI Key: InChIKey=NLXPBTDXNHRYAS-ULOPGSAPSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50180146   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50180146
PNG
((3S,5S)-2-aza-bicyclo[2.2.1]heptane-3,5-dicarboxyl...)
Show SMILES OC(=O)[C@H]1CC2CC1[C@H](N2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c10-7(11)5-2-3-1-4(5)6(9-3)8(12)13/h3-6,9H,1-2H2,(H,10,11)(H,12,13)/t3?,4?,5-,6-/m0/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>4.00E+5n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Activity against human EAAT2 transfected in HEK293 cells


J Med Chem 49: 172-8 (2006)


Article DOI: 10.1021/jm0508336
BindingDB Entry DOI: 10.7270/Q2GM86WB
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50180146
PNG
((3S,5S)-2-aza-bicyclo[2.2.1]heptane-3,5-dicarboxyl...)
Show SMILES OC(=O)[C@H]1CC2CC1[C@H](N2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c10-7(11)5-2-3-1-4(5)6(9-3)8(12)13/h3-6,9H,1-2H2,(H,10,11)(H,12,13)/t3?,4?,5-,6-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>4.00E+5n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Activity against human EAAT1 transfected in HEK293 cells


J Med Chem 49: 172-8 (2006)


Article DOI: 10.1021/jm0508336
BindingDB Entry DOI: 10.7270/Q2GM86WB
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50180146
PNG
((3S,5S)-2-aza-bicyclo[2.2.1]heptane-3,5-dicarboxyl...)
Show SMILES OC(=O)[C@H]1CC2CC1[C@H](N2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c10-7(11)5-2-3-1-4(5)6(9-3)8(12)13/h3-6,9H,1-2H2,(H,10,11)(H,12,13)/t3?,4?,5-,6-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>4.00E+5n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Activity against human EAAT3 transfected in HEK293 cells


J Med Chem 49: 172-8 (2006)


Article DOI: 10.1021/jm0508336
BindingDB Entry DOI: 10.7270/Q2GM86WB
More data for this
Ligand-Target Pair