BDBM50181008 (S)-N-hydroxy-4-(4-(4-hydroxybut-2-ynyloxy)phenylsulfonyl)-2,2-dimethylthiomorpholine-3-carboxamide::CHEMBL206815::TMI-05::US9266848, Apratastat::US9365529, Apratastat

SMILES: CC1(C)SCCN([C@H]1C(=O)NO)S(=O)(=O)c1ccc(OCC#CCO)cc1

InChI Key: InChIKey=MAVDNGWEBZTACC-UHFFFAOYSA-N

Data: 22 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50181008   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Disintegrin and metalloproteinase domain-containing protein 17 (Human)	BDBM50181008 (TMI-05 | (S)-N-hydroxy-4-(4-(4-hydroxybut-2-ynylox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	7.4	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Human)	BDBM50181008 (TMI-05 | (S)-N-hydroxy-4-(4-(4-hydroxybut-2-ynylox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	158	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Human)	BDBM50181008 (TMI-05 | (S)-N-hydroxy-4-(4-(4-hydroxybut-2-ynylox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Human)	BDBM50181008 (TMI-05 | (S)-N-hydroxy-4-(4-(4-hydroxybut-2-ynylox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	126	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Human)	BDBM50181008 (TMI-05 | (S)-N-hydroxy-4-(4-(4-hydroxybut-2-ynylox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	158	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Human)	BDBM50181008 (TMI-05 | (S)-N-hydroxy-4-(4-(4-hydroxybut-2-ynylox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	440	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Human)	BDBM50181008 (TMI-05 | (S)-N-hydroxy-4-(4-(4-hydroxybut-2-ynylox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Human)	BDBM50181008 (TMI-05 | (S)-N-hydroxy-4-(4-(4-hydroxybut-2-ynylox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Human)	BDBM50181008 (TMI-05 | (S)-N-hydroxy-4-(4-(4-hydroxybut-2-ynylox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
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Collagenase 3 (Human)	BDBM50181008 (TMI-05 | (S)-N-hydroxy-4-(4-(4-hydroxybut-2-ynylox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Interstitial collagenase (Human)	BDBM50181008 (TMI-05 | (S)-N-hydroxy-4-(4-(4-hydroxybut-2-ynylox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Interstitial collagenase (Human)	BDBM50181008 (TMI-05 | (S)-N-hydroxy-4-(4-(4-hydroxybut-2-ynylox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	145	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 10 (Human)	BDBM50181008 (TMI-05 | (S)-N-hydroxy-4-(4-(4-hydroxybut-2-ynylox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	71	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (Human)	BDBM50181008 (TMI-05 | (S)-N-hydroxy-4-(4-(4-hydroxybut-2-ynylox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	85	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Human)	BDBM50181008 (TMI-05 | (S)-N-hydroxy-4-(4-(4-hydroxybut-2-ynylox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	82	n/a	n/a	n/a	n/a	n/a	n/a
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Stromelysin-1 (Human)	BDBM50181008 (TMI-05 | (S)-N-hydroxy-4-(4-(4-hydroxybut-2-ynylox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Interstitial collagenase (Human)	BDBM50181008 (TMI-05 | (S)-N-hydroxy-4-(4-(4-hydroxybut-2-ynylox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	145	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Human)	BDBM50181008 (TMI-05 | (S)-N-hydroxy-4-(4-(4-hydroxybut-2-ynylox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	7.4	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 10 (Human)	BDBM50181008 (TMI-05 | (S)-N-hydroxy-4-(4-(4-hydroxybut-2-ynylox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	71	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 9 (Human)	BDBM50181008 (TMI-05 | (S)-N-hydroxy-4-(4-(4-hydroxybut-2-ynylox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	85	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Human)	BDBM50181008 (TMI-05 | (S)-N-hydroxy-4-(4-(4-hydroxybut-2-ynylox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	82	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Stromelysin-1 (Human)	BDBM50181008 (TMI-05 | (S)-N-hydroxy-4-(4-(4-hydroxybut-2-ynylox...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair