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BDBM50181674 6'-methoxy-6-oxo-1,6-dihydro-[3,3']bipyridinyl-5-carboxylic acid [4-(4-methyl-piperazin-1-ylmethyl)-phenyl]-amide::CHEMBL203354

SMILES: COc1ccc(cn1)-c1c[nH]c(=O)c(c1)C(=O)Nc1ccc(CN2CCN(C)CC2)cc1

InChI Key: InChIKey=LSBZCOGIERJUBR-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50181674   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Insulin receptor


(Homo sapiens (Human))
BDBM50181674
PNG
(6'-methoxy-6-oxo-1,6-dihydro-[3,3']bipyridinyl-5-c...)
Show SMILES COc1ccc(cn1)-c1c[nH]c(=O)c(c1)C(=O)Nc1ccc(CN2CCN(C)CC2)cc1
Show InChI InChI=1S/C24H27N5O3/c1-28-9-11-29(12-10-28)16-17-3-6-20(7-4-17)27-24(31)21-13-19(15-26-23(21)30)18-5-8-22(32-2)25-14-18/h3-8,13-15H,9-12,16H2,1-2H3,(H,26,30)(H,27,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.38E+4n/an/an/an/an/an/a



ChemBridge Research Laboratories and ChemBridge Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against IRK


J Med Chem 49: 1006-15 (2006)


Article DOI: 10.1021/jm050824x
BindingDB Entry DOI: 10.7270/Q2H994T6
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50181674
PNG
(6'-methoxy-6-oxo-1,6-dihydro-[3,3']bipyridinyl-5-c...)
Show SMILES COc1ccc(cn1)-c1c[nH]c(=O)c(c1)C(=O)Nc1ccc(CN2CCN(C)CC2)cc1
Show InChI InChI=1S/C24H27N5O3/c1-28-9-11-29(12-10-28)16-17-3-6-20(7-4-17)27-24(31)21-13-19(15-26-23(21)30)18-5-8-22(32-2)25-14-18/h3-8,13-15H,9-12,16H2,1-2H3,(H,26,30)(H,27,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a



ChemBridge Research Laboratories and ChemBridge Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against ALK


J Med Chem 49: 1006-15 (2006)


Article DOI: 10.1021/jm050824x
BindingDB Entry DOI: 10.7270/Q2H994T6
More data for this
Ligand-Target Pair