BDBM50182959 2-(4-hydroxy-5-phenyl-1H-pyrazol-3-yl)-1H-benzoimidazole-5-carboxamidine::CHEMBL204997

SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1n[nH]c(c1O)-c1ccccc1

InChI Key InChIKey=CKSIVONWCYACAP-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50182959   

TargetCoagulation factor IX(Homo sapiens (Human))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50182959(2-(4-hydroxy-5-phenyl-1H-pyrazol-3-yl)-1H-benzoimi...)
Affinity DataKi:  50nMAssay Description:Binding affinity to F9aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50182959(2-(4-hydroxy-5-phenyl-1H-pyrazol-3-yl)-1H-benzoimi...)
Affinity DataIC50:  249nMAssay Description:Inhibition of human activated factor XI using pyroGlu-Pro-Arg-pNA as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50182959(2-(4-hydroxy-5-phenyl-1H-pyrazol-3-yl)-1H-benzoimi...)
Affinity DataIC50:  950nMAssay Description:Inhibition of recombinant human activated factor VII using H-D-Lle-Pro-Arg-pNA as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCoagulation factor IX(Homo sapiens (Human))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50182959(2-(4-hydroxy-5-phenyl-1H-pyrazol-3-yl)-1H-benzoimi...)
Affinity DataIC50:  53nMAssay Description:Inhibition of activated factor IX (unknown origin) using CH3SO2-D-CHG-Gly-Arg-pNA:AcOH as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50182959(2-(4-hydroxy-5-phenyl-1H-pyrazol-3-yl)-1H-benzoimi...)
Affinity DataIC50:  700nMAssay Description:Inhibition of activated factor X (unknown origin) using CH3O-CO-D-CHG-Gly-Arg-pNA-AcOH as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed