BDBM50183714 CHEMBL206993::N-(4-(2-(hydroxyamino)-2-oxoethyl)-1-pivaloylpiperidin-4-yl)-4-((2-methylquinolin-4-yl)methoxy)benzamide

SMILES Cc1cc(COc2ccc(cc2)C(=O)NC2(CC(=O)NO)CCN(CC2)C(=O)C(C)(C)C)c2ccccc2n1

InChI Key InChIKey=OVSGONSKJHXDJO-UHFFFAOYSA-N

Data  4 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50183714   

TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50183714(CHEMBL206993 | N-(4-(2-(hydroxyamino)-2-oxoethyl)-...)
Affinity DataKi: >2.13E+3nMAssay Description:Binding affinity to MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50183714(CHEMBL206993 | N-(4-(2-(hydroxyamino)-2-oxoethyl)-...)
Affinity DataKi: >3.33E+3nMAssay Description:Binding affinity to MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50183714(CHEMBL206993 | N-(4-(2-(hydroxyamino)-2-oxoethyl)-...)
Affinity DataKi: >4.95E+3nMAssay Description:Binding affinity to MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50183714(CHEMBL206993 | N-(4-(2-(hydroxyamino)-2-oxoethyl)-...)
Affinity DataKi: >5.03E+3nMAssay Description:Binding affinity to MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Sus scrofa (pig))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50183714(CHEMBL206993 | N-(4-(2-(hydroxyamino)-2-oxoethyl)-...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of porcine TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50183714(CHEMBL206993 | N-(4-(2-(hydroxyamino)-2-oxoethyl)-...)
Affinity DataIC50:  102nMAssay Description:Inhibition of LPS-stimulated TNFalpha production in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed