BDBM50183784 (2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-N4-hydroxy-3-(hydroxymethyl)-2-(4-methoxyphenyl)succinamide::(2S,3R)-N4-((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-N1-hydroxy-2-hydroxymethyl-3-(4-methoxy-phenyl)-succinamide::CHEMBL72511::N*4*-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-N*1*-hydroxy-2-hydroxymethyl-3-(4-methoxy-phenyl)-succinamide::PKF-242-484::TNF-484

SMILES CNC(=O)[C@@H](NC(=O)[C@@H]([C@H](CO)C(=O)NO)c1ccc(OC)cc1)C(C)(C)C

InChI Key InChIKey=IOLRUMINDIUCLJ-RRFJBIMHSA-N

Data  8 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50183784   

TargetCollagenase 3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183784((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to recombinant MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50183784((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataKi:  0.5nMAssay Description:Inhibitory potency against Matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183784((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity to recombinant TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183784((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataKi:  0.600nMAssay Description:Inhibitory potency against Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50183784((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataKi:  0.900nMAssay Description:Inhibitory potency against Matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50183784((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataKi:  0.900nMAssay Description:Binding affinity to recombinant MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183784((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataKi:  1nMAssay Description:Binding affinity to recombinant MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183784((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataKi:  1.10nMAssay Description:Inhibitory potency against Matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor(Homo sapiens (Human))
Preclinical Research Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50183784((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataIC50:  48nMAssay Description:Inhibitory activity against tumor necrosis factor alpha (TNF-alpha) production in LPS-stimulated human PBMCsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183784((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataIC50:  56nMAssay Description:Inhibition of TACE in human PBMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50183784((2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxo...)
Affinity DataIC50:  48nMAssay Description:Inhibition of LPS/interferon gamma-stimulated TNFalpha release from HPBMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed