BDBM50183837 (R)-1-((4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)methyl)pyrrolidine-2-carboxamide::CHEMBL206955

SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1CN1CCC[C@@H]1C(N)=O

InChI Key InChIKey=VFRFZAHRSWUZQO-GOSISDBHSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50183837   

TargetRho-associated protein kinase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50183837((R)-1-((4-(3-chloro-4-fluorophenylamino)-7-methoxy...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50183837((R)-1-((4-(3-chloro-4-fluorophenylamino)-7-methoxy...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10/8/9(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50183837((R)-1-((4-(3-chloro-4-fluorophenylamino)-7-methoxy...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JNKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha/beta/gamma(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50183837((R)-1-((4-(3-chloro-4-fluorophenylamino)-7-methoxy...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PKAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50183837((R)-1-((4-(3-chloro-4-fluorophenylamino)-7-methoxy...)
Affinity DataIC50:  6nMAssay Description:Inhibition of EGFR in presence of 2 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50183837((R)-1-((4-(3-chloro-4-fluorophenylamino)-7-methoxy...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of SAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50183837((R)-1-((4-(3-chloro-4-fluorophenylamino)-7-methoxy...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MAPKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50183837((R)-1-((4-(3-chloro-4-fluorophenylamino)-7-methoxy...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50183837((R)-1-((4-(3-chloro-4-fluorophenylamino)-7-methoxy...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50183837((R)-1-((4-(3-chloro-4-fluorophenylamino)-7-methoxy...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50183837((R)-1-((4-(3-chloro-4-fluorophenylamino)-7-methoxy...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of SGKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50183837((R)-1-((4-(3-chloro-4-fluorophenylamino)-7-methoxy...)
Affinity DataIC50:  6nMAssay Description:Inhibition of EGFR in presence of 2 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50183837((R)-1-((4-(3-chloro-4-fluorophenylamino)-7-methoxy...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed