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BDBM50184143 1-(4'-trifluoromethyl-biphenyl-2-carbonyl)-2,3-dihydro-1H-indole-5-carboxylic acid ((S)-2-morpholin-4-yl-2-oxo-1-phenyl-ethyl)-amide::CHEMBL437318

SMILES: FC(F)(F)c1ccc(cc1)-c1ccccc1C(=O)N1CCc2cc(ccc12)C(=O)N[C@H](C(=O)N1CCOCC1)c1ccccc1

InChI Key: InChIKey=JITLFKUHJGMLLE-HKBQPEDESA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50184143   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Microsomal triglyceride transfer protein


(Homo sapiens (Human))
BDBM50184143
PNG
(1-(4'-trifluoromethyl-biphenyl-2-carbonyl)-2,3-dih...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccccc1C(=O)N1CCc2cc(ccc12)C(=O)N[C@H](C(=O)N1CCOCC1)c1ccccc1
Show InChI InChI=1S/C35H30F3N3O4/c36-35(37,38)27-13-10-23(11-14-27)28-8-4-5-9-29(28)33(43)41-17-16-25-22-26(12-15-30(25)41)32(42)39-31(24-6-2-1-3-7-24)34(44)40-18-20-45-21-19-40/h1-15,22,31H,16-21H2,(H,39,42)/t31-/m0/s1
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Similars

Article
PubMed
n/an/a 72.7n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of MTP in canine liver microsomes


Bioorg Med Chem Lett 16: 3039-42 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68
More data for this
Ligand-Target Pair