BDBM50184924 1-((1S,2R,5S)-5-(4-cyanophenyl)bicyclo[3.1.0]hexan-2-yl)-3-(4-fluoro-3-(trifluoromethyl)phenyl)-1-(3-(4-methylpiperazin-1-yl)propyl)urea::CHEMBL205285::N-[trans-5-(4-cyanophenyl)bicyclo[3.1.0]hex-2-yl]-N'-[4-fluoro-3-(trifluoromethyl)phenyl)-N-[3-(4-methyl-1-piperazinyl)propyl]-urea
SMILES CN1CCN(CCCN([C@@H]2CC[C@@]3(C[C@H]23)c2ccc(cc2)C#N)C(=O)Nc2ccc(F)c(c2)C(F)(F)F)CC1
InChI Key InChIKey=QXIJKQBZACKAMG-OROMBRFGSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 50184924
Affinity DataKi: 1.20nMAssay Description:Displacement of [3H]GW803430 from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.70nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cellMore data for this Ligand-Target Pair
Affinity DataKi: 2.70nMAssay Description:Binding affinity to MCHR1More data for this Ligand-Target Pair
Affinity DataKi: 2.70nMAssay Description:Inhibition of 125I-MCH binding to human MCH-R1 expressed in CHO cell membranesMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+7nMAssay Description:Inhibition of CYP2B6More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+7nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+7nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+7nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Schering-Plough Research Institute
Curated by ChEMBL
Schering-Plough Research Institute
Curated by ChEMBL
Affinity DataIC50: 52nMAssay Description:Inhibition of hERG channel by voltage clamp assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair