BDBM50185042 CHEMBL206081::N-[1-(1,3-benzodioxol-5-ylmethyl)piperidin-4-yl]-7-methoxy-4-oxo-4H-chromene-2-carboxamide

SMILES COc1ccc2c(c1)oc(cc2=O)C(=O)NC1CCN(Cc2ccc3OCOc3c2)CC1

InChI Key InChIKey=BLVUILRZDGFJPZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50185042   

TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50185042(CHEMBL206081 | N-[1-(1,3-benzodioxol-5-ylmethyl)pi...)
Affinity DataIC50:  6nMAssay Description:Displacement of [125I]-MCH from MCHr1 expressed in IMR32 (I3.4.2) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50185042(CHEMBL206081 | N-[1-(1,3-benzodioxol-5-ylmethyl)pi...)
Affinity DataIC50:  11.5nMAssay Description:Displacement of [3H]dofetilide from hERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50185042(CHEMBL206081 | N-[1-(1,3-benzodioxol-5-ylmethyl)pi...)
Affinity DataIC50:  73nMAssay Description:Antagonist activity at MCHr1 assessed as inhibition of MCH-mediated calcium ion release in intact IMR32 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50185042(CHEMBL206081 | N-[1-(1,3-benzodioxol-5-ylmethyl)pi...)
Affinity DataIC50:  11nMAssay Description:Displacement of [125I]MCH from MCHr1 expressed in IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed