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BDBM50185448 CHEMBL3823633

SMILES: COc1cnccc1-c1cnn(c1)-c1ccc(cc1)N1CCN(C)CC1

InChI Key: InChIKey=MLLPZNSEVXTAIR-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50185448   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Maternal embryonic leucine zipper kinase


(Homo sapiens (Human))
BDBM50185448
PNG
(CHEMBL3823633)
Show SMILES COc1cnccc1-c1cnn(c1)-c1ccc(cc1)N1CCN(C)CC1
Show InChI InChI=1S/C20H23N5O/c1-23-9-11-24(12-10-23)17-3-5-18(6-4-17)25-15-16(13-22-25)19-7-8-21-14-20(19)26-2/h3-8,13-15H,9-12H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 64n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of MELK catalytic domain (unknown origin) preincubated for 20 mins followed by addition of KinEASE STK S1 peptide as substrate in presence...


J Med Chem 59: 4711-23 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00052
BindingDB Entry DOI: 10.7270/Q2MK6FTG
More data for this
Ligand-Target Pair