BDBM50186267 2'-deoxy-5'-uridylic acid::CHEMBL211312::dUMP

SMILES O[C@H]1C[C@@H](O[C@@H]1COP(O)(O)=O)n1ccc(=O)[nH]c1=O

InChI Key InChIKey=JSRLJPSBLDHEIO-SHYZEUOFSA-N

Data  4 KI

PDB links: 5 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50186267   

TargetThymidylate synthase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50186267(2'-deoxy-5'-uridylic acid | CHEMBL211312 | dUMP)
Affinity DataKi:  2.26E+3nMAssay Description:Inhibition of amethopterin-resistant Lactobacillus casei thymidylate synthetase-catalyzed 5-BrdUMP dehalogenation by absorbance analysis in absence o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetThymidylate synthase(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50186267(2'-deoxy-5'-uridylic acid | CHEMBL211312 | dUMP)
Affinity DataKi:  6.50E+3nMAssay Description:Competitive inhibition of purified mouse Ehrlich ascites tumor cell thymidylate synthetase using 5-[3H]-2'-deoxyuridine 5'-phosphate as substrate aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Bos taurus)
TBA

Curated by ChEMBL
LigandPNGBDBM50186267(2'-deoxy-5'-uridylic acid | CHEMBL211312 | dUMP)
Affinity DataKi:  8.00E+3nMAssay Description:Competitive inhibition of purified calf thymus thymidylate synthetase using 5-[3H]-2'-deoxyuridine 5'-phosphate as substrate after 7 mins by double r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDeoxyuridine triphosphatase, putative(Trypanosoma cruzi)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50186267(2'-deoxy-5'-uridylic acid | CHEMBL211312 | dUMP)
Affinity DataKi:  1.84E+4nMAssay Description:Inhibition of Trypanosoma cruzi dUTPase at 1 mMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed