BDBM50187686 CHEMBL3828074::US10526329, Compound 2::US11072611, Compound 2::US11104665, WO2014/139882 Example 2::US11591342, Compound GLPG1690::US20230295159, Example GLPG1690::US20240327407, Compound GLPG1690::US9670204, 2 2-((2-ethyl-6-(4-(2-(3-hydroxyazetidin-1-yl)-2-oxoethyl)piperazin-1-yl)-8-methylimidazo[1,2-a]pyridin-3-yl)(methyl)amino)-4-(4-fluorophenyl)thiazole-5-carbonitrile::WO2014139882, Compound 2

SMILES: CCc1c(n2cc(cc(c2n1)C)N3CCN(CC3)CC(=O)N4CC(C4)O)N(C)c5nc(c(s5)C#N)c6ccc(cc6)F

InChI Key: InChIKey=REQQVBGILUTQNN-UHFFFAOYSA-N

Data: 1 KI  34 IC50

PDB links: 2 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 35 hits for monomerid = 50187686   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Autotaxin (Human)	BDBM50187686 (CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Autotaxin (Human)	BDBM50187686 (CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Autotaxin (Human)	BDBM50187686 (CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	131	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Autotaxin (Human)	BDBM50187686 (CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Autotaxin (Human)	BDBM50187686 (CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Autotaxin (Human)	BDBM50187686 (CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Autotaxin (Human)	BDBM50187686 (CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Autotaxin (Human)	BDBM50187686 (CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Autotaxin (Rat)	BDBM50187686 (CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	131	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Autotaxin (Human)	BDBM50187686 (CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	242	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50187686 (CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Autotaxin (Human)	BDBM50187686 (CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Mouse)	BDBM50187686 (CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	224	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Autotaxin (Human)	BDBM50187686 (CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Autotaxin (Human)	BDBM50187686 (CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.0100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Autotaxin (Human)	BDBM50187686 (CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	131	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Autotaxin (Human)	BDBM50187686 (CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Autotaxin (Human)	BDBM50187686 (CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50187686 (CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Autotaxin (Human)	BDBM50187686 (CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Autotaxin (Human)	BDBM50187686 (CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Autotaxin (Human)	BDBM50187686 (CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Autotaxin (Human)	BDBM50187686 (CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Autotaxin (Human)	BDBM50187686 (CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Autotaxin (Human)	BDBM50187686 (CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Autotaxin (Human)	BDBM50187686 (CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	245	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Autotaxin (Human)	BDBM50187686 (CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	112	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Autotaxin (Human)	BDBM50187686 (CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	300	n/a	n/a	n/a	n/a	8.5	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Autotaxin (Rat)	BDBM50187686 (CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	508	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50187686 (CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Mouse)	BDBM50187686 (CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	418	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50187686 (CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Autotaxin (Human)	BDBM50187686 (CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	131	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Autotaxin (Rat)	BDBM50187686 (CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	542	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Autotaxin (Human)	BDBM50187686 (CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...) Show SMILES Show InChI	GoogleScholar	UniChem		15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair